SUBACCUTE TOXICITY YELLOW FLOWER EXTRACT (Cananga odorata) ON HISTOPATHOLOGY OF WHITE RAT HEART (Rattus norvegicus)

Background: The inflammatory process is influenced by chemical mediators such as nitric oxide (NO), cytokines, and arachidonic acid metabolites. Currently, herbal treatment techniques are preferred the public because they generally do not cause side effects. therapeutic effect of plants comes from content phytochemicals that have strong antioxidant activity. Objective study was to examine phytochemical anti-inflammatory effects Cananga odorata. Methodology: this research a two-stage research, namely in vitro vivo tests. Many previous studies proven activity only related but also its ability suppress production pro-inflammatory cytokines. This still being developed using variety plants. One whose been studied field health-medicine ylang flower. odorata (Annonaceae) or flower plant tropical has fragrant petals thrives without requiring special care. Results were total phenol 1,06 %w/w IC50 DPPH spectrophotometric examination 808.86 ppm. These results show good extract. Research rats showed decrease blood glucose levels lipid profiles. Furthermore, toxicity test did any experimental rats. Histological appearances no differences cardiovascular disease model mice with standard-feeding mice. Conclusions: ethanol extract on histopatology white rat heart.